Maria Francisca, a wealthy young heiress and her friend Mariana De Castro, a young protestant widow, are accused of witchcraft and taken before the Inquisition. Maleficarum is the story of Francisca, a wealthy orphan and Mariana, her widowed protestant friend, who live surrounded by a town in which they are the center of hostile gossip. Francisco Verdugo, the Inquisitor, has his own ambitions. He has his greedy eyes on the orphan heiress’s properties, but he needs a pretext. A confrontation in the street among a group of girls gives him the perfect excuse to arrest Mariana and Francisca and enchain them in the horror chambers of the Inquisition, leading them to a frightful end as they are convicted of witchcraft.